Photo of Dr. Mark N. Isaacs, MD, F.A.A.F.P.

With over 25 years experience, Dr. Mark Isaacs is recognized as a pioneer in the field of ultrasound guided sclerotherapy and endovenous ablation procedures.


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Dr. Mark Isaacs @ Vein Specialists of Northern California  

Dr. Mark Isaacs @ Vein Specialists of Northern California  

Dr. Mark Isaacs @ Vein Specialists of Northern California

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Vein Specialists of Northern California  


Please Note: This link will direct you to a third-party website unaffiliated with (, where you're able to request or schedule an appointment online with Dr. Mark Isaacs.

Accepting New Patients?

Yes, Dr. Mark N. Isaacs is accepting new patients at this office.


1981 N Broadway, Suite 427, Walnut Creek, CA 94596

Office Hours

  Open Lunch Close

Office Details

Doctor Specialty Vascular & Interventional Radiology
Accepting New Patients? Yes
Practice Specialty Vascular Surgery
Hospital Affiliation
  • John Muir Medical Center
Languages Spoken English, Spanish

We are located three blocks off 680 off Ygnacio Valley Rd. and two walking blocks from the Walnut Creek BART station.

1 mile from Broadway Plaza Mall

Our building has a parking lot and there is metered parking on the front and side street as well if no parking spots available in lot. 


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Insurance Accepted  

  • Anthem
  • Blue Cross and Blue Shield of Texas (BCBSTX)
  • Blue Cross Blue Shield
  • Blue Cross of California
  • Blue Shield
  • Blue Shield Freedom Blue PFFS
  • Blue Shield of California
  • Cigna
  • Empire Blue Cross
  • Empire Bluecross
  • Health Net
  • Independence Blue Cross
  • Medicare Part B
  • UHC West (Formerly Pacificare)
  • United Healthcare
  • WellPoint

About Dr. Isaacs
Dr. Isaacs



Dr. Mark Isaacs has always been at the leading edge in the diagnosis and treatment of vein disorders. Today, Dr. Isaacs is the premiere vein doctor in Northern California, specializing in diseases of the vascular system and vein treatment since 1990.

Mark Isaacs earned his medical degree at the University of California San Francisco School of Medicine. He then completed his residency training at an affiliated hospital of the University of Minnesota. Dr. Isaacs earned board certification in family medicine in 1979, meaning he has special expertise in this area.

Dr. Mark Isaacs has always been a leader in the field of phlebology, which focuses on diagnosing and treating vein problems, such as varicose veins and spider veins. Dr. Isaacs was in the first group to receive board certification by the American College of Phlebology in 2008. Dr. Mark Isaacs is a Diplomate of the American Board of Phlebology, which means he possesses extra skills in diagnosing and treating comprehensive vein problems.

Dr. Isaacs was one of the first physicians to recognize the effectiveness of duplex ultrasound to guide physicians during the treatment of varicose veins. The Food and Drug Administration, or FDA, asked Mark Isaacs to join the original FDA trial study of endovenous laser, a treatment method that is now the gold standard for the non-surgical treatment of large varicose veins.

Vein Specialists of Northern California would proudly like to announce that we were chosen to be the first office in the Bay Area to treat patients suffering from venous reflux disease with the VenaSeal™ closure system.  This new, minimally invasive procedure uses an advanced medical adhesive to coapt (close) the diseased vein in patients with symptomatic venous reflux disease.   The VenaSeal™ closure system is the only procedure to use adhesive to coapt and close the vein with high closure rates across three clinical trials.  Patients treated with the VenaSeal™ closure system usually have minimal to no bruising, and are able to quickly resume normal daily activities.  Unlike other heat based treatments, VenaSeal™ does not require the use of injected tumescent anesthesia, and eliminates the risk of nerve injury associated with thermal based procedures.  In most cases, patients do not need to use compression stockings post procedure.  The VenaSeal™ closure system is the only non-thermal, non-tumescent, non-sclerosant procedure approved for use in the U.S. that uses an advanced medical adhesive that closes the diseased vein.  This procedure is office based and done in under an hour.

Today, Dr. Mark Isaacs is on the hospital staff of John Muir Medical Center and belongs to both the California Medical Association and the California Academy of Family Physicians. He continues to be a clinical faculty member at U.C.S.F. and the University of Minnesota. He also serves on the faculty of the American College of Phlebology and the Union Internationale de Phlebologie.

Dr. Mark Isaacs brings state-of-the-art diagnostic and treatment technology to Northern California, specializing in the comprehensive care of varicose veins, spider veins, and other vascular problems.


Sources: &


Conditions Treated 

  • Spider Veins
  • Varicose Veins and Varicosities
  • Vein Disorders
  • Venous Insufficiency
  • Venous Ulcers

Services & Procedures

  • Closure (endovenous ablation radiofrequency)
  • Endovenous chemical ablation
  • EVLT (Endovenous Laser Ablation)
  • Gentle Surface Sclerotherapy
  • VenaSeal

Education & Training  

Medical School


Languages Spoken  

  • English
  • Spanish
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